Spectromètre de masse Isoprime Precision

Galerie et schémas techniques

Description

Caractéristiques

• Un spectromètre de masse de rapport d’isotopes stables innovant conçu pour évoluer avec vos recherches
• Basculer rapidement entre les différents préparateurs
• Poursuivre tous les thèmes de recherche avec la mesure simultanée de faisceau ionique multi-collecteur
• Développer des systèmes d’introduction sur mesure pour de nouvelles expériences en utilisant le module de contrôle d’entrée Novel (NICM) et l’édition de nouvelles méthodes via le logiciel « ionOS Workflow Method Editor »
• Les performances en IRMS les plus élevées dans un instrument compact

Spécifications techniques

+

44/28

CO

28, 29, 30 ¹⁸O 30/28

SO

48, 49, 50 ³³S 49/48 CO₂ δ¹³C > 1 ≤ 0.020

MFC

MFC by up to 85%

N O

30, 31, 44, 45, 46 ¹⁵Nα, ¹⁵Nβ 31/30

m/z

44

H₂

δH 100 ≤ 0.10

IRMS

• No requirement for additional heated lines for SO₂

Logs

system continuously analyzes the data in real-time to

N₂

δ¹⁵N 100 ≤ 0.010

O₂

δ¹⁸O 100 ≤ 0.010

Pass

Send email to system user/administrator

easy

• Administrator and user access levels with password

nC17

nC18

pump

• The world’s highest precision ¹⁸O analysis of water samples ground waters

CO₂

44, 45, 46 ¹³C 45/44

Depth

460 mm 2

Inlet

Mon

N₂O

44, 45, 46 ¹⁵N 45/44 Gas Isotope Sample Size Internal Precision

SO₂

δ³⁴S 100 ≤ 0.010

Design

• Fully enclosed, highly compact benchtop instrument with horizontally aligned

Height

650 mm

Radius

108 mm

Report

When you are happy with your data, you can then report your data to your favourite software package, or utilize

Weight

102 kg

high C

S ratio using an elemental analyzer, or ethane/propane isotopes in the

ionOS.

can be easily configured to exactly match your process laboratory ecosystem. isotopes"

³⁴S

50/48 δ¹⁸O using cold finger ≤ 0.030

¹⁸O

34/32 δ¹⁸O ≤ 0.016

BrCH₃

94, 96 ⁸¹Br 96/94

ClCH₃

50, 52 ³⁷Cl 52/50

1σ(‰)

‰/nA

Selector

Gas

analysis

control databases

Forensics

• Sports doping • Archeology Chemicals • Medical

Graphical

Drag and drop your analysis with

LiquiFace

iso DUAL INLET

analysis.

markets, allows us to effectively serve the academic the perfect starting point for your research to go in any • Simultaneous measurement of up to 10 ion beams

membranes

Valve

positions

analysis

Instrument

Collaborative

Resolution

Greater than 110 m/Δm @ 10 % valley separation

Sleep mode

analysis

¹⁵Nbulk

45/44

Agriculture

• Soil and plant science Energy • Oil and gas exploration

Gas species

Masses Isotopes Ratio H₂ ²H ≤ 0.20 n/a

Quick Tasks

Notifications

Statistical

Quality Public

development

methods from the

integration

working

iso FLOW GHG

charts

makes method

devices and sub- integration

together and

Interpret Now that you have mapped your chromatograms you can get on with interpreting your results quicker and faster

• Criminal

• Food and • Pharmaceutical

Environmental

• Ecology • Pollution • Geochemistry

Water removal

Source Isolation

your results.

Instantly perform

Control Module

welcome surprise how simple and flexible ionOS, isoprime

Small footprint

High data quality investigations flavorings

Solenoid valves

Multiport valves Gauges and MFCs Thermocouples Relays Stepper motors

logical methods

common controls, real-time data

of interest and

reporting for even simpler interpretation of intra-compound variability.

Dimensions Width

595 mm

Mass range @ 3kV

1 – 76 amu

names to the map

from a single injection, or all and apply automatically to the

organic material

• Only truly integrated TOC-IRMS system for analysis of dissolved

quick and simple

toolbox

• Oceanography

• Climate change • Hydrology

Faraday detectors

The self-tensioning design of our latest generation electron impact (EI) source

Great flexibility

High sensitivity Small footprint High data quality

IRMS ever created

your research in any direction. Combined with our dedicated ionOS software and backed by our expert technical support,

a ribbon tool bar

• Third party IRMS data processing

mapped injections

mapped injections

separation column

• Eliminates the need for sample extraction and purification

Calculated columns

Sample grouping

control available.

workflow. Creating a recorded method is quick and

Isotope calibration

Reporting Peak Maps

Task-based workflow

and drop approach with sample-by-sample method Importing and exporting data Development and support

are mapped together

first compound of interest as required until map is complete

for ¹⁸O analysis

• O₂ furnace recharge gives long term analytical robustness in ¹³C mode

parallel processing

• Multiple languages supported

A world of potential

numerical readbacks, gauges or charts. This allows you to

Complete integration

Analyze the most Almost 50% smaller than Achieve the highest

Ion beam acceleration

0 – 5 kV ¹⁸O 32/30

Rapid inlet switching

centrION KEY FEATURES

of all inlet systems,

challenging samples any other commercial analytical performance

H₃ correction factor

≤ 8.0 ppm/nA

batches automatically.

order lets you quickly assess the performance of all

including novel inlets

with exceptionally high stable isotope ratio mass with the most precise

ion source sensitivity

spectrometer instrument available

Critical specifications

Optional detector configurations

Dynamic amplifier range

0 – 100 V

Simultaneous acquisition

Up to 10 ion beams across a mass range of ±25 % at any one time

• Example sample types

greenhouse gases, dissolved nitrates

Continuous flow (CF) mode

1,100 molecules CO₂/ion 45, 46* 32/28

Intuitive workflow design

methods to provide more flexible sample handling. This ionOS can also be integrated into your LIMS system to You can quickly and easily find samples, batches and tasks

a-glance instrument status

robust audit trail

arrives in the laboratory.

• Automatic dilution of sample gases

Chromatography continued...

Dual Inlet

Excellence in IRMS analysis

isoprime precisION – take your research in any direction

Max. measurable single mass

96 amu

User access and permissions

performed, and its success, as well as allowing the system

Straightforward user control

(CMOS/TTL compatible)

Automatic background check m/z

28

international reference scales

performance

Make your database work for you

sample results for numerous

System within defined tolerance?

Fail

streamlining laboratory workflows.

helps to standardize analytical protocols and data processing, robustly to simplify analyses and eliminate errors. gives you the ability to quickly and easily find and manage all

Compact, high performance ion optics

Ion beam separation is achieved using a highly stable, computer-controlled,

Art.-No. 05 005 646, 05 / 2020 APhone

+49 (0) 6184 9393-0 | [email protected] | www.elementar.com

• 10 year warranty on TCD and furnace

• Compatible with Gerstel® and CTC autosamplers for SPME/HS analysis

• Excellent chromatography performance

• Micro-volume cryogenic cold-finger makes analysis of very • Example sample types: pure gases, biological and

manufacturing and supporting high quality

international footprint, with a global sales and exceptional analytical power and unrivalled flexibility with auto-resistor switching for enriched isotope

Ion source efficiency Dual inlet (DI) mode

800 molecules CO₂/ion Air 28, 29, 30, 32, 34, 36, 40, 44, - 40/28

Unrivaled intelligent control of your IRMS

Fast and robust data processing for even the most complex samples

clear, at-a-glance status for each action.

methods. When developing new workflows, users can IonVantage data from older instruments, or data from

hardware and software systems that work in

maintenance and training to match our customers' 1,100 molecules CO₂/ion (CF mode) and

compromising on flexibility or performance.

statistical analyses – such as averages and standard

• Capable of analyzing materials with a C

S ratio of >5,000:1 GC5

analysis and isotope ratio mass spectrometry

they have both the high quality instrumentation mass spectrometer, offering market-leading gas ionization

flow interface ensure easy operation without

reference materials, and provides instant access to

Simplifying stable isotope analysis workflows

“I'm very impressed by ionOS, especially the calibrations part. It's basically

and straightforward as possible, by providing

providing specialist consultancy, technical support, • Improved gas ionization performance of

helping to provide consistent, reliable data.

for complete peace of mind.

and aggregation. It allows standard and custom

defined groupings, allowing easy calculation of summary

ArDB is a combined database management tool and

Results are recorded and organized together with all

and commercial sectors around the world – our

direction. across a ±25 % mass range for novel multi-collector

microorganisms, crude oils, glass fiber filters

fragrances, VOCs, PAHs, POPs

(IRMS). We have over 40 years' experience in the

and knowledgeable technical support necessary and mass resolution performance in the most compact

We aim to make stable isotope analysis as simple

instruments are used in over 80 countries – experiments

• Built especially for stable isotope analysis

• Flexible and powerful peak detection and integration

IRMS market, and we pride ourselves on designing,

to achieve the highest possible performance. Our footprint possible. This benchtop instrument combines • 100 V amplification for large dynamic range samples,

providing greater insights from every experiment.

your stable isotope analysis data directly within ionOS.

• Quick Tasks for routine and regular workflows

being lost due to error

accelerating instrument programming for frequently

required, and the system can be programmed to provide

harmony to deliver high quality, reliable results.

growing needs. 800 molecules CO₂/ion (DI mode)

it offers complete control, method development and

instrument checks to data processing – ensures optimal identification and multi-point, multi-isotope calibration, consistent and flexible approach to data handling. Combined

peak refinements across multiple sample injections

• Automatic software updates

security. Password protected instrument access and

for internal review in a custom-definable format, and can

to support the IRMS community. Designed to work in

a wide range of powerful features to match the everyday complete automation of laborious manual tasks using systems. It can also be used to simplify processing of data

and maintain methods visually, without the need for

behavior based on either input parameters or the real- terms – such as the sample name, sample type, method,

isoprime precisION and ionOS to construct, maintain

of the database. Powerful data visualization capabilities

performed operations. ionOS offers a number of pre-

email notifications for status alerts – such as completed

programming languages, using a straightforward drag

rapidly search local and remote directories, displaying the

simplifying troubleshooting. The System monitor log

ion beam does not exceed a pre-defined threshold. The

• Peak maps for quick compound identification and

• Windows 10, 64-bit compatible

Elementar is a global technology leader in elemental

We work closely with our customers to ensure that isoprime precisION is our flagship stable isotope ratio

Every action that the isoprime precisION performs is

customization and easily defined process logic to build ionOS employs a user-friendly iArc file format to simplify ionOS is continually updated with new and improved

The Method Workflow Designer makes it easy to create

allows the system to automatically change its acquisition create a seamless laboratory workflow. directly from the home screen. Simply start typing search

The Novel Inlet Control Module (NICM) is an optional

Developing methods Application Programming Interface (API) • Add additional sample loops and gas flows to an

The software records the information associated with

ensure that monitoring gas peaks exist, that the expected

allows the system to be almost 50 % smaller than any

entire IRMS workflow to ensure the very best quality

between users, and ensures that SOPs are adhered to,

each task, and any post-analytical changes to the records, – to meet user-defined thresholds

hardware device offering a revolutionary approach to

ionOS method workflows offer intelligent, parameter- ionOS provides an API that enables the task list to be existing inlet system

requirements, and provides live system data, such as

• Automate control of an offline preparation system

simultaneously, allowing you to run experiments that

Method Recorder

solutions that push the boundaries of stable isotope

service network and nine offices across major to meet the needs of virtually any application, providing analysis

two compounds, to be performed and applied to entire

Toggling the view between grouped data and acquisition

validity of your data. Customizable Compound-to-Com-

large data sets a quick and easy process,

• Reliable results, even for low-microgram samples

by GC

• Sleep/Wake-up function to reduce gas consumption

• Hyphenation with GC-QMS, GC-QQQMS and GC-TOFMS systems possible

can operate the system, and administrators can freely

resolution of technical issues. The audit log provides a

choose any combination of time-based and event-driven

other manufacturer’s stable isotope instrumentation. Search

helping to track baseline instrument performance over

list is paused, or prevent a task from starting if a system

interfacing custom experimental set-ups with isoprime

based control of your novel inlet, making it easy to controlled remotely. This allows, for example, tasklists • Develop a laser ablation system for tree rings or mineral

materials – ensuring the broadest possible range of

and dual inlet modes. Combined with our dedicated

pound reporting provides innovative and detailed data

saving us a huge amount of time and

the large quantities of data generated by modern high

tools enable analytical results to be statistically reduced

• Method Workflow Designer graphical user interface

• Sample Loss Prevention protects valuable samples from

Its benchtop design and integrated centrION continuous

multi-point, multi-isotope calibration using standard

Your research goals should not be limited by hardware,

switch devices on or off as required, or create logic-based

concert with our range of IRMS instruments and inlets,

needs of IRMS users. Intelligent automation – from pre-run functions such as peak mapping, standard compound generated on third party IRMS platforms, providing a

data processing, simplifying day-to-day activities and

results while minimizing the need for user intervention. This performing all the necessary calculations transparently and with the software’s advanced instant search functionality, this

enables it to switch seamlessly between inlet systems,

of detection for the smallest sample sizes across any

or more tasks that can be run at the push of a button,

provides at-a-glance warnings if user attention is

permissions functions to provide comprehensive process

tolerance. These logs can be easily archived or exported

precisION. It provides customizable input/output ports

manage interactions between the various inputs and generated in your LIMS to be imported directly into ionOS, cross-sections

time. This makes it easy to check when a test was last

status error is detected.

• Patented ball valve for blank-free sample transfer

• Agilent 7890B GC with split/splitless, PTV or on-column injectors

After working hard to collect, prepare and analyze your

CRAIG BARRIE //

Quick Tasks allows pre-defined templates containing one

A colored LED status light on the front of the instrument

The system can be combined with a variety of continuous

isoprime precisION is one of the most powerful stable

every action, providing a comprehensive audit trail and

number of sample peaks are detected and that a particular

flow peripheral inlet systems – as well as dual inlet

isotope ratio mass spectrometers ever created, with

group. This prevents methods and standards being edited

parameters and methods used, which operator performed Automatic stability checks

includes data of all system parameters before analysis,

user can also define the number of failures before the task

isoprime precisION is the most compact fully functional

Data quality is dependent on many factors, including

isotope analysis, offering a range of advanced features

user interface. Its clear iconography and structure offers save time when processing large IRMS data sets. It offers limited to real-time data generated on Elementar IRMS

programmed and scheduled via ionOS’s Task List. Tasks

and edit methods. archiving, transfer and sharing of data. This format features, with automatic updates to ensure you have

technologies for the measurement of water and carbonate

exceptional ionization efficiency in both continuous flow

• Direct injection mode for bulk isotope measurements

precision measurements of carbonate and water samples • Extremely compact benchtop system

• Fractionation-free wet chemical oxidation at 90 °C

• The only dual inlet instrument capable of extremely high only a change of sample needle

• Real-time and fast data processing using multi-core

protection

a variety of components required for custom experimental

operation in real time.

analytics platform that can be optionally used alongside

associated meta data, allowing simple, fast interrogation

auto-lock time out features ensure only authorized users

also be sent to Elementar engineers to aid diagnosis and

can be either individually created, copied from existing

ensures that sample information and meta data – systems access to the latest innovations. If your instrument is not

gas and electricity. The instrument can be programmed to

• Internalized connections – no exposed fused silica

ionOS software has been developed exclusively for stable

ionOS is designed to be simple to use, with an intuitive ionOS offers an array of powerful features designed to Crucially, ionOS’s advanced analytical capabilities are not

ionOS’s Calculated Columns feature supports any number

For batch processing, ionOS can automatically organize Map 01_Multiple sample chromatograms 02_User populates the map with the 03_Additional compounds are added

offering fully automated handling and dilution of sample

application.

or adjusted by each user, either individually or by user

each task a unique ID. This ensures full traceability of the

single NICM box, so there are no limits to the amount of

for creating a fully functional and optimized method

the isobaric separation of ²H-H and ³He isotopes. This

interpretation. ionOS offers complete control of the

throughput technologies, ArDB simplifies data processing

for easier interpretation.

• Clear and simple iconography and structure, with at-

• No external spreadsheet software required, ensuring a

• Instant search function makes finding data quick and

• Integration with ArDB software

define exactly which settings or features can be accessed

comprehensive record of all analytical activities, assigning

easy; simply record your interactions with a schematic or

4x 5 V digital outputs

finement options available directly from the chromatogram

the peaks of interest have shifted to.”

ionOS offers built-in, fully customizable user access and

to pause analysis if a critical parameter goes out of

samples the complex task of data interpretation begins…

Oil Isotope Lab

so NICM is designed to support a broad range of different

processes – for example, setting the state of a custom

wake up and perform Good For Go routines at a pre-defined

capillaries

workflows or selected from a list of pre-defined ‘Quick

Logical methods settings, voltages, pressures, readbacks, etc. – is not connected to the internet, software updates are available

• Modern, clean design with simple user interface using

algorithms

• Multi-point, multi-isotope calibration of raw data to

• System Data Log keeps a record of instrument

IRMS on the market, with a unique electrostatic filter for

sample preparation, analytical methodology and data

for immediate interpretation. Coupled with our unique Peak

hundreds of peaks, of which only a select

ionOS’s Sleep/Wake-up function significantly reduces the

Vent • No requirement for compressed air

regardless of the analytical technique. Designed to handle

straightforward, while integrated multi-variate analysis

require more devices than it is possible to operate with a

A recorded method provides a great starting point

• Liquid chromatography interface for ¹³C measurements

• High precision pure gas analyzer • Switch between water and carbonate analysis with

and manage a centralized database of analytical results –

make discovering trends and relationships within datasets

applications. Its centrION continuous flow interface system

range of inlet systems, this offers unrivalled limits

calculations, such as calculating the δ-difference between

information, such as averages and standard deviations.

configured Quick Tasks – such as running peak centers for

runs or faults requiring user attention – allowing walk-

input and output types. This makes it possible to integrate

valve based on a thermocouple input – editing system

other IRMS, making it ideal for space-limited laboratories.

results at every step. The software offers automatic,

specialist programming skills. It avoids the use of complex

time status of a device. task, description, batch ID, date, etc. – and the system will

• Uses a single temperature-programmable desorption (TPD)

organics

Fast and robust data processing for the most complex samples

“Our lab runs whole crude oils with hundreds of peaks, of which only a select

Tasks’, then instantly added to the Task List, providing a

ionOS offers logic-based decision making within your lost when transferring results. You can also easily import from the log-in section of the Elementar support website.

allowing you to control multiple novel inlet devices through

outputs in real time. Each interactive method workflow or integration of your Elementar devices into a larger • Build your own carbonate digestion system for "clumped

consumption of precious laboratory resources, such as helium

GC Pump

each data point relative to a multi-point calibration curve.

designer. saving users hours of manual post-analysis processing time.

ionOS goes further than any other stable isotope software to

GeoMark Research, Houston, USA

multi-point isotope calibration of raw data yielding results

“Our lab runs whole crude oils with

of complex scenarios – including inter-sample calculations

results by sample type, name or ID, or according to user-

• Integrated autosampler with options for up to 240 sample

• Exceptional dissolved organic carbon and bound nitrogen isotope

between peripheral inlet systems, allowing up to five devices

Monitoring gas

full control solution for your custom inlet, without the need

16x digital inputs

• Reliable results for sample sizes up to 7 mg (abs) carbon

• High temperature combustion of recalcitrant compounds yields

time, ensuring that it is ready to run as soon as the operator

• Selective water removal membranes

– including any combination of elemental analysis (EA), total

injection valve

detectors are supplied with a 10 year guarantee against failure.

extending filament lifetime and increasing maintenance intervals.

N₂, CO₂ and SO₂ gases as a single operation – or users can

away operation with complete confidence.

• Automatic chemical reagent delivery using on-board peristaltic

small (5 μg) carbonate samples possible geological carbonate materials, body fluids, ice cores,

working with the latest firmware version from our development team.

ion source and Faraday detectors, for easier maintenance and less downtime.

Refine 04_Simply drag and drop compound 05_Remove unwanted compounds

06_Manually override peak integration

clays, fruits and vegetables, meat, honey, keratin, muscle, collagen,

natural gases, alkanes, biomarkers, lipids, amino acids, aromas and

diagnostics and a comprehensive understanding of instrument behavior,

magnetic sector and 108 mm of mass dispersion. This provides a unit mass

• Excellent analysis of large sample sizes up to 30 mg (abs) carbon

• Online measurement of ¹³C, ¹⁵N, ²H and ¹⁸O in compounds separated

• Low temperature pyrolysis options with unique backflush technology

• Optimized to maintain chromatography integrity

10 ion beams simultaneously, allowing a broad range of Faraday detector

of gas loads, with an extremely stable H₃+ correction factor of ≤8.0 ppm/nA and

additional H₂ geometry. isoprime precisION is also able to monitor up to

excellent ionization efficiency and dependable performance over a broad range

multi-elemental, multi-point isotope calibration of raw data for immediate

customized reports – in XLSX or PDF formats – accordingacross multiple injections, you will have confidence in the individual compounds across multiple injections for GC-makes selecting only those peaks across

supply to the ionization source for long term peak-center stability. ionOS

Compact geometry

spreadsheet. Calibrations are based on a custom-defined library of isotopic

data processing features display the relevant results ininterpretation. Use the Comparison View for side-by-side reported consistently across all injections, accounting foreffort. Even when there is a change in re-

interpretation of results, without needing to export your data to a separate

to your specific requirements. All of ionOS's advanced IRMS data processing. This ensures that each compound is

configurations for the analysis of chlorine and bromine isotopes, atmospheric

no memory effect when transitioning between isotopically distinct gases. The

helping to detect and correct potential faults before they happen. The system

resolution of 110 (10 % valley definition), allowing isotope measurements of

ion source tuning – using in-depth readbacks to provide a detailed on-board

benchtop convenience and high performance, using a 90° stigmatic focusing

of ²H-H and ³He isotopes, allowing H₂ analysis in continuous flow without

source, resulting in minimal doubly ionized gas molecules. As a result, it offers

• Sleep/Wake-up function to reduce gas consumption • Example sample types

ground water, plant water, waste water,

also offers optional automatic firmware updates, ensuring that all systems are

masses up to 96 amu. The horizontal arrangement also simplifies access to the

ionOS goes further than any other stable isotope software, providing automated

The software offers straightforward generation ofMaps feature, which instantly rationalizes GC compounds The unique Peak Maps feature can instantly rationalizenumber are of interest. Peak mapping

standards, using transparent calculation procedures and visualizations to show

a batch results grid, which also functions as a reportinterpretation of chromatograms with synchronized peak re- potential minor variations in retention time and potentiallytention time ionOS can determine where

provides full automated system control – with a choice of automatic or manual

The isoprime precisION’s compact, horizontal analyzer configuration combines

• Patented ability to measure ¹⁵N, ¹³C, ³⁴S and ²H from a single sample

• High temperature ²H pyrolysis of compounds at 1,450 °C

gas ratios, CO₂ ‘clumped isotopes’ and N₂O/NO and SO₂/SO fragments. All Faraday

system also features a self-aligning filament with a unique thorium coating,